Publications

Published in: J. Med. Chem. 2026, 69, 4, 3984–3998 DOI: 10.1021/acs.jmedchem.5c01954 Authors: Henry A. Onyami, Stephen Brand, Delphin Baud, Gregory S. Basarab, Natalie Hawryluk, Stacie Canan, Magdalene D. Togoh, Ramatu Abdulai, Robert Eduku, Mohammed Awal, Richard Boakye Owoare, Barsha Chatterjee [TCGLS Member], Debasish Singha Roy [TCGLS Member], Amal Kr Ray...

Published in: Bioorganic & Medicinal Chemistry Letters, Volume 137, August 2026, 130623 DOI: 10.1016/j.bmcl.2026.130623 Authors: Nazir Uddin, Sudipta Roy [TCGLS Member], Rwivoo Baruah, Anjali Nareda, Gitish K. Dutta, Paresh Nath Chatterjee ABSTRACT Bis(indolyl)methanes (BIMs) are significant molecular scaffolds comprising nitrogen heterocycles that exhibit notable biological and pharmacological properties. This work represents an alternative and novel method for the synthesis of BIMs...

Published in: Cell Cycle Volume 25, 2026 – Issue 1, Pages 1-15 DOI: 10.1080/15384101.2026.2675348 Authors: Sharanya Roy, Swastika Rakhshit, Sayak Chakraborty, Sampriti Chakraborty, Soumava Jana [TCGLS Member], Prasmita Sircar, Aditi Nayak Abstract: Polyploid giant cancer cells (PGCCs) showcase a unique and often undervalued subpopulation within tumors that performs a major role in...

Published in: Chemistry – A European Journal DOI: 10.1002/chem.202503349 Authors: Md. Akram Ali [TCGLS Member], Satyajit Bera, Rajib Chakraborty [TCGLS Member], Susanta Kumar Mondal [TCGLS Member], SupriyaBhunia, Tapas Sardar [TCGLS Member], Sabyasachi Chakraborty, Subhas Samanta ABSTRACT Photopharmacology offers a novel approach to eliminate side effects of chemotherapy treatment via site-specific activation of light-active anticancer agents, which are...

Published in: Naunyn-Schmiedeberg’s Archives of Pharmacology DOI: 10.1007/s00210-025-04958-3 Authors: SoumitraMoulick [TCGLS Member], Tannisha Bhattacharya [TCGLS Member], Dijendra Nath Roy Abstract: The escalating prevalence of antimicrobial resistance (AMR) and severe inflammation associated with Pseudomonas aeruginosa infections emphasize the urgent need for alternative therapeutic strategies. This study investigates quercetin, a naturally occurring bioflavonoid, for...

Published in: RSC Med. Chem., 2025,16, 6109-6123 DOI: 10.1039/D5MD00776C Authors: Sourav Sarkar, Vedant Tripathi, Surajit Sadhukhan [TCGLS Member], Jhuma Bhadra and Santanu Bhattacharya Abstract: To overcome neomycin’s limited efficacy against complex Gram-positive and Gram-negative co-infections, we have developed a novel guanidinium-linked neomycin–lipid conjugate (guanidino Neo-lipid). This multifunctional construct integrates three...

Published in: J. Med. Chem. 2025, 68, 21, 23485–23520 DOI: 10.1021/acs.jmedchem.5c02394 Authors: Suraksha Gahalawat, Sneha Ray, Xiaoyu Zhang, Xiaoyi Deng, Yan Han, Zhe Chen, Aloysus Lawong, David M. Shackleford, Kasiram Katneni, Gong Chen, Peng Li, Alice Ng, Longjin Zhong, Meiyu Hu, Mitchell McInerney, Wen Wang, Jessica Saunders, Daniel Collins, Jaya Jayaseelan,...

Published in: Synthesis DOI: 10.1055/a-2755-9816 Authors: Priyadarshi Manna [TCGLS Member], Rusmita Mukherjee [TCGLS Member], Mrinalkanti Kundu[TCGLS Member], Susanta Sekhar Adhikari Abstract: Diaryl sulfides, diaryl selenides, and their derivatives are crucial scaffolds in the fields of organic chemistry and drug discovery. We report a practical and broadly applicable strategy for additive-free...

Published in: ACS Bio Med Chem Au 2025, 5, 5, 821–839 DOI: 10.1021/acsbiomedchemau.5c00058 Authors: Malkeet Kumar, Anees Ahmad,Anna Caroline Campos Aguiar,Sarah El Chamy Maluf,Anwar Shamim, Mariana Ferrer, Guilherme E. Souza, Marcos L. Gazarini, Dhelio B. Pereira, Thomas W. von Geldern, Delphine Baud, Barry Jones, Susanta Kumar Mondal [TCGLS Member], Paul...

Published in: Chemical Biology & Drug Design (2025), 105(6), e70132 DOI: 10.1021/acsomega.5c04858 Authors: Victor Oliveira Gawriljuk, Gabriela Dias Noske, Rafaela Sachetto Fernandes, Aline Minalli Nakamura, Marjorie C. L. C. Freire, Mariana Ortiz Godoy, Vinicius Bonatto, Rafael Chelucci, Adriano Andricopulo, Malina A. Bakowski, Karen C. Wolff, Laura Riva, Jeremy N. Burrows,...

Published in: Bioorganic & Medicinal Chemistry Letters Volume 130, 1 January 2026, 130436 DOI: 10.1016/j.bmcl.2025.130436 Authors: Mohd Usman Mohd Siddique, Deepak Shilkar, Vasavi Garisetti, Sheikh Murtuja, Suzanne Kaptein, Pieter Leyssen, Johan Neyts, Vinay N. Basavanakatti, Subodh Mondal, Susanta Kumar Mondal[TCGLS Member], Gayathri Dasararaju, Velmurugan Devadasan, Barij Nayan Sinha, Venkatesan Jayaprakash Abstract:...

Published in: Chemical Biology & Drug Design (2025), 105(6), e70132 DOI: 10.1111/cbdd.70132 Authors: Sanjay Kumar [TCGLS Member], Rajib Chakraborty [TCGLS Member], Chandreyee Roy [TCGLS Member], Sohini Basu [TCGLS Member], Arun K. Hajra [TCGLS Member], Priyam Sen [TCGLS Member], Debajyoti Paul [TCGLS Member], Karabi Phukan [TCGLS Member], Subhasis Roy [TCGLS Member],...

Published in: Antimicrobial Agents and Chemotherapy, Vol. 69, No. 9 DOI: 10.1128/aac.01783-24 Authors: Emma Y. Mao, William Nguyen, GourangaP. Jana[TCGLS MEMBER], BikashC. Maity[TCGLS MEMBER], Samuel Pazicky, Carlo Giannangelo, Janette Reader, Mufuliat T. Famodimu, Lyn-Marie Birkholtz, Michael J. Delves, Darren J. Creek, Zbynek Bozdech, Benoît Laleu, Jeremy N. Burrows, Brad E. Sleebs, Maria R. Gancheva, Danny W. Wilson Abstract: Drug resistance is steadily undermining the efficacy of frontline anti-malarials, highlighting the urgent need for novel therapies with alternative mechanisms of action. The chemical addition...

Published in: Chemical Biology & Drug Design (2025), 105(6), e70132 DOI: 10.1111/cbdd.70132 Authors: Sanjay Kumar [TCGLS Member], Rajib Chakraborty [TCGLS Member], Chandreyee Roy [TCGLS Member], Sohini Basu [TCGLS Member], Arun K. Hajra [TCGLS Member], Priyam Sen [TCGLS Member], Debajyoti Paul [TCGLS Member], Karabi Phukan [TCGLS Member], Subhasis Roy [TCGLS Member],...

Published in: Org. Biomol. Chem., 2025,23, 7448-7455 DOI: 10.1039/D5OB00687B Authors: Nazir Uddin, Sudipta Roy [TCGLS Member], Santanab Giri, c Gitish K. Dutta *a and Paresh Nath Chatterjee *d Abstract: An alternative and unique approach for synthesizing 3-substituted isoindolinones via Lewis acid-catalyzed C–C bond-breaking reactions has been reported. For this purpose, we successfully generated N-acyliminium ion intermediates from two different substrates [through...

Published in: Chemical Biology & Drug Design (2025), 105(6), e70132 DOI: 10.1111/cbdd.70132 Authors: Sanjay Kumar [TCGLS Member], Rajib Chakraborty[TCGLS Member], Chandreyee Roy[TCGLS Member], Sohini Basu[TCGLS Member], Arun K. Hajra[TCGLS Member], Priyam Sen[TCGLS Member], Debajyoti Paul[TCGLS Member], Karabi Phukan[TCGLS Member], Subhasis Roy[TCGLS Member], Rammohan Bera[TCGLS Member], Trisha Mondal[TCGLS Member], Sabyasachi Chakraborty,...

Published in: Synthesis 2025; 57(14): 2207-2220 DOI: 10.1055/a-2605-1321 Authors: Suman Kumar Joardar [TCGLS Member], Gunturu Prabhakar Rao, Jakkani Soumya [TCGLS Member],Sourasree Midya [TCGLS Member], Ramanand Das, Mrinalkanti Kundu [TCGLS Member] Abstract: We herein report an efficient and convenient protocol for the Ni(II)-catalyzed ortho-C(sp2)–H arylation as well as alkylation using 8-aminoimidazo[1,2-a]pyridine (8-AIP)...

Published in: Microbial Pathogenesis Volume 204, July 2025, 107624 DOI: 10.1016/j.micpath.2025.107624 Authors: Soumitra Moulick [TCGLS Member], Rammohan Bera[TCGLS Member], Dijendra Nath Roy Abstract: The emergence of multidrug-resistant Escherichia coli is considered a severe threat to global health, largely attributed to the bacterium’s ability to expel antibiotics via efflux pump systems. This study explores the antibacterial efficacy of a...

Published in: International Journal of Biological Macromolecules Volume 303, April 2025, 140469 DOI: 10.1016/j.ijbiomac.2025.140469 Authors: Shayeri Chatterjee Ganguly, Soumya Ganguly[TCGLS Member], Beduin Mahanti, Purna Chandra Pal, Swarnajit Dutta, Subhabrota Majumdar Abstract: Albumin, an excellent nanocarrier in the genre of drug delivery, endows high biocompatibility, non-immunogenicity, biodegradability, and safety. This study aims to explicate the anti-inflammatory potential of hydrophobic garcinol. Nanostructures were fabricated...

Published in: Medical Oncology, January 2025 DOI: 10.1007/s12032-025-02605-8 Authors: Laavanya Das, Subhadip Das [TCGLS Member] Abstract: Cancer is a major global health issue that is usually treated with multiple therapies, such as chemotherapy and targeted therapies like immunotherapy. Immunotherapy is a new and alternative approach to treating various types of...

Published in: Synthesis, January 2025 DOI: 10.1055/s-0040-1720160 Authors: Manna, Priyadarshi [TCGLS Member]; Chatterjee, Arunima [TCGLS Member]; Kundu, Mrinalkanti [TCGLS Member]; Rao, G. Prabhakar [TCGLS Member]; Mukherjee, Rusmita [TCGLS Member]; Podder, Swarnali [TCGLS Member]; Datta, Bandita; Adhikari, Susanta Abstract: Arylamines are essential building blocks that are found in biol. important substances, agrochems., and natural products. One of the...

Published in: Journal of Medicinal Chemistry J. Med. Chem. 2025, 68, 590−637 DOI: 10.1021/acs.jmedchem.4c02394 AuthorsZhe Nie, Roger Bonnert, Jet Tsien, Xiaoyi Deng, Christopher Higgs, Farah El Mazouni, Xiaoyu Zhang,Renzhe Li, Nhi Ho, Victoria Feher, Janet Paulsen, David M. Shackleford, KasiramKatneni, Gong Chen,Alice C. F. Ng, Mitchell McInerney, Wen Wang, Jessica...

Published in : European Journal of Medicinal Chemistry Volume 280, 15 December 2024, 116921 DOI : 10.1016/j.ejmech.2024.116921 Authors : Jon Kyle Awalt, Wenyin Su, William Nguyen, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Saishyam Ramesh, Kate J. Fairhurst, Tomas Yeo, Heekuk Park, Anne-Catrin Uhlemann, Bikash ChandraMaity [TCGLS Member], Nirupam De [TCGLS Member], Partha Mukherjee [TCGLS Member], Arnish Chakraborty [TCGLS Member], Alisje Churchyard, Mufuliat T. Famodimu, MichaelJ. Delves, Jake Baum, Nimisha Mittal…Brad E. Sleebs Abstract : Drug resistance against antimalarials is rendering them increasingly ineffective and so there is a...

Published in: ACS Pharmacol. Transl. Sci. 2024, 7, 9, 2662–2676 Authors: Subhasis Roy (TCGLS Member), Monali Chakrabarti(TCGLS Member), Trisha Mondal(TCGLS Member), Tapas Kumar Das(TCGLS Member), Tonmoy Sarkar(TCGLS Member), Sebak Datta(TCGLS Member), Mrinalkanti Kundu(TCGLS Member), Manish Banerjee(TCGLS Member), Onkar Prakash Kulkarni Abstract: The role of autotaxin (ATX)-lysophosphatidic acid (LPA) is yet...

Published in: International Journal of Biological MacromoleculesVolume 278, Part 1, October 2024, 134651 Authors: ShayeriChatterjee Ganguly, Beduin Mahanti, Soumya Ganguly (TCGLS Member), Subhabrota Majumdar Abstract: Garcinia indica, known as kokum, has been extensively researched for its therapeutic potential. Among the wide variety of phytoconstituents, garcinol is the most efficacious, holding anti-inflammatory, anti-cancer, and anti-diabetic properties. Hydrophobicity and a...

Published in: J. Org. Chem. 2024, 89, 16, 11467–11479 Authors: Tapas Kumar Das (TCGLS Member), Prasanjit Ghosh, Shibaji Ghosh, Sajal Das Abstract: Selective installation of halo and nitro groups in heterocyclic backbone through a transition-metal-catalyzed C–H bond activation strategy is immensely alluring to access high-value scaffolds. Here in, we disclosed N-pyrimidyl-directed...

Published in: Microbial drug resistance (Larchmont, N.Y.) Journal; Article 2024 Authors: Soumitra Moulick (TCGLS Member) and Dijendra Nath Roy Abstract: The rise in antibiotic resistance among bacterial pathogens, particularly Staphylococcus aureus, has become a critical global health issue, necessitating the search for novel antimicrobial agents. S. aureus uses various mechanisms to resist antibiotics, including the activation of...

Published in: ChemMedChem, Pages: e202400549, Journal; Article, 2024 DOI: 10.1002/cmdc.202400549 Authors: Trent D. Ashton, Petar P. S. Calic, Madeline G. Dans, Zi Kang Ooi, Qingmiao Zhou, Katie Loi, Kate E. Jarman, Josephine Palandri, Deyun Qiu, Adele M. Lehane, Bikash Maity (TCGLS Member), Nirupam De (TCGLS Member), Mufuliat T. Famodimu, Michael J. Delves, Emma Y. Mao, Maria R. Gancheva, Danny W. Wilson, Mrittika Chowdury, Tania F. de Koning-Ward, Delphine Baud, Stephen...

Published in: European Journal of Medicinal Chemistry, Volume 276, 5 October 2024, 116677 DOI: 10.1016/j.ejmech.2024.116677 Authors: Petar P.S. Calic, Trent D. Ashton, Mahta Mansouri, Katie Loi, KateE. Jarman, Deyun Qiu, Adele M. Lehane, Sayantan Roy [TCGLS Member], Gunturu P. Rao [TCGLS Member], Bikash Maity [TCGLS Member], Sergio Wittlin, Benigno Crespo, Franciso-Javier Gamo, Ioanna Deni, David A. Fidock, Mrittika Chowdury, Tania F. de Koning-Ward, Alan F. Cowman, Paul F. Jackson, Delphine Baud, Stephen Brand, Benoît Laleu, Brad E. Sleebs Abstract: Emerging resistance to current antimalarials is reducing their effectiveness and therefore there is a need to develop...

Published in: Journal of Medicinal Chemistry, ASAP DOI: 10.1021/acs.jmedchem.4c01241 Authors: Trent D. Ashton, Petar P. S. Calic, Madeline G. Dans, Zi Kang Ooi, Qingmiao Zhou, Josephine Palandri, Katie Loi, Kate E. Jarman, Deyun Qiu, Adele M. Lehane, Bikash Chandra Maity[TCGLS Member], Nirupam De[TCGLS Member],Carlo Giannangelo, Christopher A. MacRaild, Darren J....

Published in: ChemistrySelect, Volume9, Issue30, August 12, 2024, e202400574 DOI: 10.1002/slct.202400574 Authors: Nazir Uddin, Sudipta Roy [TCGLS Member], Sayantan Roy [TCGLS Member], Dipankar Paul, Geetanjali Basumatary, Gitish K. Dutta, Paresh Nath Chatterjee Abstract: An alternative approach to synthesize bis-indolylmethanes (BIMs) via a unique p-toluenesulfonic acid (PTSA) catalyzed dual Csp3−Csp2 bond-breaking reaction has been reported here. In the reported protocol,...

Published in: Journal of Medicinal Chemistry, ASAPDOI: 10.1021/acs.jmedchem.4c01154 Authors: Godwin AkpekoDziwornu,Donald Seanego,Stephen Fienberg,Monica Clements,Jasmin Ferreira, Venkata S. Sypu, Sauvik Samanta, Ashlyn D. Bhana, Constance M. Korkor,Larnelle F. Garnie, Nicole Teixeira, Kathryn J. Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge,Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato(TCGLS Member), Arnish Chakraborty(TCGLS Member),...

Authors: Pati, Tanmay K.; Molla, Sabir Ali; Ghosh, Narendra Nath; Kundu, Mrinalkanti(TCGLS Member); Ajarul, Sk; Maity, Pradip ; Khamrai, Uttam(TCGLS Member); Maiti, Dilip K. Abstract: N-substituted 2-pyridones as an N,O-directing group for selective C(sp2)-H activated thiolation, selenylation and sulfonamidation of ortho C-H bonds of benzamides was demonstrated . This method utilizes a cost-effective Cu(II)-salt catalyst instead of precious...

Published in: eBioMedicine Volume 102, April 2024, 105073 Authors: Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen,...

Published in: Nat Commun 15, 937 (2024). DOI: 10.21203/rs.3.rs-3198291/v1 Authors: Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, KrittikornKumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, NutpakalKetprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana...

Published in: SCIENCE, 23 Nov 2023, Vol 382, Issue 6673, pp. 935-940 Authors: GANESH M. NAWKAR, MARTINA, ANUPAMA GOYAL (TCGLS MEMBER), EMANUEL SCHMID-SIEGERT, JÉRÉMY FLEURY, ANTONIO MUCCIOLO, DAMIEN DE BELLIS, MARTINE TREVISAN, ANDREAS, AND CHRISTIAN FANKHAUSER DOI: https://www.science.org/doi/10.1126/science.adh9384 Abstract: In plants, light direction is perceived by the phototropin photoreceptors, which...

Published in: J. Org. Chem DOI: 10.1021/acs.joc.3c01852 Authors: Arun Kumar Hajra(TCGLS Member), Prasanjit Ghosh*, Priyanka Paul(TCGLS Member), Mrinalkanti Kundu*(TCGLS Member), and Sajal Das* Abstract: An operationally simple and efficient protocol for copper(II)-mediated, picolinamido-directed C8–H sulfonamidation of 1-naphthylamine derivatives with various sulfonamides has been developed. Remarkably, this cross-dehydrogenative C–H/H–N coupling reaction...

Published in: ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.3c00369 Authors: Nicolas Bosc, Eloy Felix, J. Mark F. Gardner, James Mills, Martijn Timmerman, Dennis Asveld,Kim Rensen, Partha Mukherjee(TCGLS Member), Rishi Das(TCGLS Member), Elodie Chenu, Dominique Besson, Jeremy N. Burrows,James Duffy, Benoît Laleu, Eric M. Guantai, and Andrew R. Leach Abstract: Efforts to...

Published in: Research square Journal; Preprint 2023 DOI: 10.21203/rs.3.rs-3198291/v1 Authors: Xie, Stanley C ; Wang, Yinuo; Morton, Craig J ; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A ; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S ; Park, Joon Sung ; Fairhurst, Kate J; Ketprasit, Nutpakal...

Published in: Journal, DOI : 10.1021/acs.oprd.3c00287 Author : Robey, Juliana M. S.; Maity, Sanjay; Aleshire, Sarah L.; Ghosh, Angshuman; Yadaw, Ajay K.; Roy, Subho; Mear, Sarah Jane; Jamison, Timothy F.; Sirasani, Gopal; Senanayake, Chris H.; Stringham, Rodger W.; Gupton, B. Frank; Donsbach, Kai O.; Nelson, Ryan C.; Shanahan, Charles S. Abstract : Bedaquiline...

Published in: Nature Communications, Volume: 14, Issue: 1, Pages: 3059 DOI: 10.1038/s41467-023-38774-1 Authors: Kumpornsin, Krittikorn; Kochakarn, Theerarat; Yeo, Tomas ; Okombo, John ; Luth, Madeline R.; Hoshizaki, Johanna ; Rawat, Mukul; Pearson, Richard D. ; Schindler, Kyra A. ; Mok, Sachel ; Park, Heekuk ; Uhlemann, Anne-Catrin ; Jana, Gouranga P. (TCGLS Member);...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 12, Issue : 33, Pages : 6507-6515 DOI : 10.1039/c4ob01047g Author : Malhotra, Rajesh; Dey, Tushar K.; Dutta, Swarup; Basu, Sourav; Hajra, Saumen Abstract : First regioselective ring opening of serine derived cyclic sulfamidate by hard nucleophiles like ArONa is developed, where β-elimination of serine sulfamidate ester by stronger nucleophiles...

Published in : Synthetic Communications DOI: 10.1080/00397911.2023.2205593 Authors: Chandan K. Mahato (TCGLS Member),Subhro Mandal,Mrinalkanti Kundu (TCGLS Member)&AnimeshPramanik Abstract: A proline-based, chiral bi-functional organocatalyst containing both pyrrolidine and oxadiazolone heterocycle, has been successfully applied for stereoselective aldol reactions. The replacement of polar -COOH group of proline with bioisostereoxadiazolone ring provides excellent...

Published in: ACS Infectious DiseasesVolume: 9Issue: 3Pages: 668-691 DOI: 10.1021/acsinfecdis.2c00607 Authors: Nguyen, William; Dans, Madeline G.; Currie, Iain; Awalt, Jon Kyle ; Bailey, Brodie L.; Lumb, Chris; Ngo, Anna; Favuzza, Paola; Palandri, Josephine; Ramesh, Saishyam; Penington, Jocelyn ; Jarman, Kate E.; Mukherjee, Partha (TCGLS Member); Chakraborty, Arnish (TCGLS Member); Maier, Alexander G.; van...

Publication: Journal of Medicinal Chemistry Authors: Ashton, Trent D. ; Dans, Madeline G.; Favuzza, Paola; Ngo, Anna; Lehane, Adele M. ; Zhang, Xinxin; Qiu, Deyun; Chandra Maity, Bikash (TCGLS Member); De, Nirupam (TCGLS Member); Schindler, Kyra A.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin ; Churchyard, Alisje; Baum, Jake; Fidock, David...

Authors: Tawaraishi, Taisuke; Ochida, Atsuko; Akao, Yuichiro; Itono, Sachiko; Kamaura, Masahiro; Akther, Thamina; Shimada, Mitsuyuki; Canan, Stacie; Chowdhury, Sanjoy (TCGLS Member); Cao, Yafeng; Condroski, Kevin ; Engkvist, Ola ; Francisco, Amanda; Ghosh, Sunil (TCGLS Member); Kaki, Rina; Kelly, John M.; Kimura, Chiaki; Kogej, Thierry; Nagaoka, Kazuya; Naito, Akira; Pairaudeau, Garry;...

Dr. Benoît Laleu,Kelly Rubiano,Tomas Yeo,Irene Hallyburton,Dr. Mark Anderson,Benigno Crespo-Fernandez,Dr. Francisco-Javier Gamo,Dr. Yevgeniya Antonova-Koch,Dr. Pamela Orjuela-Sanchez,Dr. Sergio Wittlin,Dr. Gouranga P. Jana (TCGLS Member),Dr. Bikash C. Maity (TCGLS Member),Elodie Chenu,Dr. James Duffy,Dr. Peter Sjö,Dr. David Waterson,Prof. Elizabeth Winzeler,Dr. Eric Guantai,Prof. David A. Fidock,Dr. Thomas G. Hansson Publication: ChemMedChem, e202200393 DOI :10.1002/cmdc.202200393 Abstract: Toolkit...

Md. Akram Ali (TCGLS Member), Rajib Chakraborty (TCGLS Member), Susanta Kumar Mondal (TCGLS Member). Supriya Bhunia, Sabyasachi Chakraborty (TCGLS Member), Subhas Samanta, Sonali Rudra (TCGLS Member) Publication: Journal of Molecular Structure Volume 1260, 15 July 2022, 132730 DOI: https://doi.org/10.1016/j.molstruc.2022.132730 Abstract: Selective binding of the pleiotropic lipid mediator prostanoid Prostaglandin E2...

Sameer Tyagi, Bruce P. McKillican, Tolani K. Salvador, Moses G. Gichinga, William J. Eberle, Russell Viner, Katarina J. Makaravage, Trey S. Johnson, C. Adam Russell, and Subho Roy (TCGLS Member) Publication: J. Org. Chem. 2022, 87, 9, 6202–6211 DOI: https://doi.org/10.1021/acs.joc.2c00440 Abstract: A bioinspired synthesis of Pinoxaden metabolites 2–5 is described herein....

Ayon Sengupta (TCGLS Member), Suvendu Maity, Pinaki Saha, Prasanta Ghosh, Sonali Rudra (TCGLS Member), Chhanda Mukhopadhyay Publication: Mol Divers. 2022 Aug 1. doi: 10.1007/s11030-022-10496-4. Online ahead of print DOI: 10.1007/s11030-022-10496-4 Abstract: Petasis aryl and allyl borations were accomplished using substituted ninhydrins, boronic acids or 2-allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and 1,2-aminophenols in Hexafluoroisopropanol (HFIP) without...

Kundu Mrinalkanti (TCGLS Member); Dutta Aditi (TCGLS Member); Mal Sajal K (TCGLS Member); Karmakar Shouvik (TCGLS Member); Mandal Aritra (TCGLS Member); Mondal Susanta K (TCGLS Member); Kumar Sanjay (TCGLS Member); Saha Soumya (TCGLS Member); Pradhan Subhankar (TCGLS Member); Sarkar Ratul (TCGLS Member); Chakrabarti Monali (TCGLS Member); Malik Pradip K (TCGLS...

Tapas Kumar Das (TCGLS Member), Mrinalkanti Kundu (TCGLS Member), Biswajit Mondal (TCGLS Member), Prasanjit Ghosh and Sajal Das Organic and Biomolecular Chemistry 2022,20, 208-218 (Published on 30th Nov 2021) DOI: https://doi.org/10.1039/D1OB01798E Abstract: A unique N,O-bidentate ligand 6-oxo-1,6-dihydro-pyridone-2-carboxylic acid dimethylamide (L1) catalyzed direct C(sp2)–H (intra/intermolecular) arylation of unactivated arenes has been...

Ashis Roy (TCGLS Member), Tonmoy Sarkar (TCGLS Member), Sebak Datta (TCGLS Member), Arup Maiti (TCGLS Member), Monali Chakrabarti (TCGLS Member), Trisha Mondal (TCGLS Member), Chaitali Mondal (TCGLS Member), Apurba Banerjee (TCGLS Member), Subhasis Roy (TCGLS Member), Soumen Mukherjee (TCGLS Member), Pragati Muley (TCGLS Member), Sabyasachi Chakraborty (TCGLS Member), Manish Banerjee...

Sarabindu Roy (TCGLS Member), Ajay Yadaw (TCGLS Member), Subho Roy (TCGLS Member), Gopal Sirasani (TCG GC Member), Aravind Gangu (TCG GC Member), Jack D. Brown (TCG GC Member), Joseph D. Armstrong III (TCG GC Member), Rodger W. Stringham, B. Frank Gupton, Chris H. Senanayake* (TCG GC Member), and David R....

Priyadarshi Manna (TCGLS Member); Mrinalkanti Kundu (TCGLS Member); Ashis Roy (TCGLS Member);Susanta Adhikari DOI : https://doi.org/10.1039/D1OB00663K Abstract: The synthesis of deuterium-labeled organic compounds is of increased interest, especially after the approval of deutetrabenazine by the Food and Drug Administration in 2014. The selective incorporation of deuterium in the place of...

DOI : https://doi.org/10.1021/acs.joc.1c00124 Abstract: Org. transformations exclusively in water as an environmentally friendly and safe medium have drawn significant interest in the recent years. Moreover, transition metal-​free synthesis of enantiopure mols. in water will have a great deal of attention as the system will mimic the natural enzymic reactions. In...

Biswajit Mondal (TCGLS Member); Prasanjit Ghosh; Mrinalkanti Kundu; (TCGLS Member); Sajal Das DOI : https://doi.org/10.1039/D0OB02510K Abstract: We demonstrate herein the first example of a palladium(II) catalyzed regioselective ortho-C(sp2)–H arylation in aqueous medium (a sustainable solvent) utilizing 8-AIP (8-aminoimidazo[1,2-a]pyridine) as a promising and removable bidentate directing group/auxilliary. This newly developed protocol...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t Volume : 16, Issue : 3, Pages : 484-498 DOI : 10.1002/cmdc.202000564 Author : Yasmin, Sabina; Cerchia, Carmen; Badavath, Vishnu Nayak; Laghezza, Antonio; Dal Piaz, Fabrizio; Mondal, Susanta K.; Atli, Oezlem; Baysal, Merve; Vadivelan, Sankaran; Shankar, S.; Siddique, Mohd. Usman Mohd.; Pattnaik, Ashok Kumar; Singh, Ravi Pratap; Loiodice, Fulvio; Jayaprakash, Venkatesan;...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 64, Issue : 1, Pages : 840-844 DOI : 10.1021/acs.jmedchem.0c01793 Author : Preston, Sarah; Garcia-Bustos, Jose; Hall, Liam G.; Martin, Sheree D.; Le, Thuy G.; Kundu, Abhijit; Ghoshal, Atanu; Nguyen, Nghi H.; Jiao, Yaqing; Ruan, Banfeng; Xue, Lian; Huang, Fei; Chang, Bill C. H.; McGee, Sean L.; Wells,...

DOI: https://doi.org/10.1039/D0OB02134B Palladium catalyzed arylation of the inert β-C(sp2)–H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of β-site selectivity and tolerates a broad spectrum...

Authors: Tanmay K. Pati (TCGLS Member), Sk Ajarul, Mrinalkanti Kundu (TCGLS Member), Deepak Tayde, Uttam Khamrai (TCGLS Member),* and Dilip K. Maiti* DOI: https://doi.org/10.1021/acs.joc.0c00941 We have identified different N-substituted 2-pyridones as inbuilt directing groups for selective C–H-activated functionalization instead of deprotecting and/or throwing away the directing groups. A robust general...

Authors : Rishi Das [TCGLS Member], Tathagata Sengupta [TCGLS Member], Shubhrajit Roy, Sumantra Chattarji, Jharna Ray DOI: 10.1097/WNR.0000000000001446 The memory-boosting property of Indian traditional herb, Convolvulus pluricaulis, has been documented in literature; however, its effect on synaptic plasticity has not yet been reported. Two important forms of synaptic plasticity known to...

Ashis Roy (TCGLS Member), Dr. Mrinalkanti Kundu (TCGLS Member), Dr. Pranab Dhar (TCGLS Member), Arnish Chakraborty (TCGLS Member), Dr. Soumen Mukherjee (TCGLS Member), Jayatri Naskar (TCGLS Member), Dr. Chhanda Rarhi (TCGLS Member), Dr. Rajib Barik (TCGLS Member), Dr. Susanta Kumar Mondal (TCGLS Member), Mushtaq Ahmad Wani, Rahul Gajbhiye, Prof. Kuldeep...

Published in: Journal Volume : 502, Pages : 119286 DOI : 10.1016/j.ica.2019.119286 Author : Asthana, Mrityunjaya; Syiemlieh, Ibanphylla; Kumar, Arvind; Lal, Ram A. Abstract : A ligand and additive-free [CuNi(bz)3(bpy)2]ClO4 catalyst system that efficiently and selectively catalyzed the oxidation of a range of primary and secondary benzylic alcs., 1-heteroaryl alcs., cinnamyl alc. and aliphatic alcs. mediated by...

Published in: Journal, General Review, Article, Review Volume : 5, Issue : 6, Pages : 2503-2519 DOI : 10.1021/acsomega.9b03686 Author : Mahato, Sanjit K.; Acharya, Chiranjit; Wellington, Kevin W.; Bhattacharjee, Pinaki; Jaisankar, Parasuraman Abstract : A review. This review deals with the recent applications of the indium trichloride (InCl3) catalyst in the synthesis of a broad spectrum of heterocyclic...

Trisha Mitra (TCGLS Member), Brindaban Roy and Mrinalkanti Kundu (TCGLS Member) The Journal of organic chemistryJournal; Article; (JOURNAL ARTICLE), 2019 DOI: 10.1021/acs.joc.9b02122 Small molecules containing a 2-​pyridone unit received much attention due to their significance in medicinal chemistry. In this regard, development of novel methodologies via metal-​catalyzed carbon-​carbon bond formation...

Bhawana Gupta (TCGLS Member), Sabyasachi Chakraborty (TCGLS Member), Soumya Saha (TCGLS Member), Sunita Chandel (TCGLS Member), Gulab Singh (TCGLS Member), Atul Kumar Baranwal (TCGLS Member), Manish Banerjee (TCGLS Member), Mousumi Chatterjee (TCGLS Member), Ashok Chaudhury. Canadian Journal of Physiology and Pharmacology Volume 94 Issue 7 Pages 788-796, 1996 DOI: 10.1139/cjpp-2015-0465 Shikonin...

Rajesh Malhotra, Chhanda Rarhi (TCGLS Member), K V Diveshkumar, Ruhee D’cunha, Rajib Barik( TCGLS Member), Pranab Dhar (TCGLS Member), Subrata Chattopadhyay (TCGLS Member), Subho Roy (TCGLS Member), Sourav Basu, Mrinalkanti Kundu (TCGLS Member), P I Pradeepkumar, Saumen Hajra Bioorganic & Medicinal Chemistry Volume 24, Issue 13, 1 July 2016, Pages...

Tathagata Sengupta(TCGLS Member), Rishi Das (TCGLS Member), Sumantra Chattarji Neuroscience Letters (2016), 633, 101-105. DOI: 10.1016/j.neulet.2016.09.031 Abstract: Acute stress has been shown to facilitate but not increase metabotropic glutamate receptor (mGluR) mediated Long-Term Depression (LTD) in the hippocampus. However, the effect of chronic stress on mGluR dependent LTD has not been...

Igawa Hideyuki; Takahashi Masashi; Shirasaki Mikio; Kakegawa Keiko; Kina Asato; Ikoma Minoru; Aida Jumpei; Okuda Shoki; Kawata Yayoi; Noguchi Toshihiro; Yamamoto Syunsuke; Fujioka Yasushi; Nakayama Masaharu; Kasai Shizuo; Maekawa Tsuyoshi; Yasuma Tsuneo; Kundu Mrinalkanti; Khamrai Uttam (TCGLS Member); Nagisa Yasutaka Bioorganic & Medicinal Chemistry Volume 24, Issue 11, 1 June...

Mahato, Chandan K. (TCGLS Member); Kundu, Mrinalkanti (TCGLS Member); Pramanik, Animesh (TCGLS Member) Tetrahedron: Asymmetry 2017, 28(4), 511-515 DOI : https://doi.org/10.1016/j.tetasy.2017.03.002 Abstract: New chiral organocatalysts are envisaged based on a pyrrolidine–pyridone conjugate and synthesized from commercially available proline employing standard protocols. These catalysts were found to be useful for asymmetric Michael...

Schwertz Geoffrey; Siggel Marc; Zwyssig Adrian; Diederich Francois; Witschel Matthias C; Aponte Raphael A; Rottmann Matthias; Schafer Anja; Rottmann Matthias; Schafer Anja; Bonnert Roger; Leartsakulpanich Ubolsree; Chitnumsub Penchit; Jaruwat Aritsara; Ittarat Wanwipa; Charman Susan A; White Karen L; Kundu Abhijit (TCGLS Member); Sadhukhan Surajit (TCGLS Member); Lloyd Mel; Freiberg Gail...

Le Thuy G; Nguyen Nghi H; Ruan Banfeng; Baell Jonathan B; Kundu Abhijit (TCGLS Member); Ghoshal Atanu (TCGLS Member); Preston Sarah; Jiao Yaqing; Chang Bill C H; Garcia-Bustos Jose; Jabbar Abdul; Gasser Robin B; Preston Sarah; Ruan Banfeng; Xue Lian; Huang Fei; Baell Jonathan B; Keiser Jennifer; Keiser Jennifer; Hofmann...

Pati Tanmay K (TCGLS Member); Debnath Sudipto; Maiti Dilip K; Kundu Mrinalkanti (TCGLS Member); Khamrai Uttam (TCGLS Member) Organic Letters 2018 20(13), 4062-4066 DOI: https://doi.org/10.1021/acs.orglett.8b01618 Abstract: A new bidentate directing group, 3-amino-1-methyl-1 H-pyridin-2-one, is introduced to achieve a powerful Pd(II) metallacycle for selective γ-C(sp(3))-H activation and arylation of aromatic and...

Chandan K. Mahato (TCGLS Member), Sayan Mukherjee, Mrinalkanti Kundu (TCGLS Member), and Animesh Pramanik The Journal of Organic Chemistry 2019 84 (2), 1053-1063 DOI: 10.1021/acs.joc.8b02393 Abstract Pyrrolidine-oxadiazolone based organocatalysts are envisaged, synthesized, and utilized for asymmetric Michael reactions. Results of the investigations suggest that some of the catalysts are indeed...

Thuy G. Le, Abhijit Kundu (TCGLS Member), Atanu Ghoshal (TCGLS Member), Nghi H. Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill C. H. Chang, Jose Garcia-Bustos, Timothy N. C. Wells, Michael J. Palmer, Abdul Jabbar, Robin B. Gasser, and Jonathan B. Baell...

Pseudo five component reaction towards densely functionalized spiro[indole-3,2′-pyrrole] by picric acid, an efficient syn-diastereoselective catalyst: insight into the diastereoselection on C(sp3)–C(sp3) axial conformation. Ayon Sengupta (TCGLS Member) Suvendu Maity, Animesh Mondal, Prasanta Ghosh, Sonali Rudra (TCGLS Member) and Chhanda Mukhopadhyay Org. Biomol. Chem., 2019,17, 1254-1265 DOI: 10.1039/C8OB02849D Abstract A new...

Thuy G. Le, Abhijit Kundu (TCGLS Member), Atanu Ghoshal (TCGLS Member), Nghi H. Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill C. H. Chang, Jose Garcia-Bustos, Timothy N. C. Wells, Michael J. Palmer, Abdul Jabbar, Robin B. Gasser, and Jonathan B. Baell Journal of Medicinal Chemistry 2019 62 (7), 3367-3380 DOI: 10.1021/acs.jmedchem.8b01790 Abstract: A phenotypic screen of two different libraries of small molecules...

Published in: Journal, Volume : 2, Issue : 18, Pages : 5206-5213 DOI : 10.1002/slct.201700677 Author : Malhotra, Rajesh; Rarhi, Chhanda; Diveshkumar, K. V.; Bommisetti, P.; Pany, Sushree Prangya P.; Roy, Subho; Pradeepkumar, P. I.; Kundu, Mrinalkanti Abstract : With an aim to engineer drug-like properties, pyridopyrimidinone based selective G4 DNA stabilizing agents, e.g., I were designed, synthesized and further...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 17, Issue : 5, Pages : 1254-1265 DOI : 10.1039/c8ob02849d Author : Sengupta, Ayon; Maity, Suvendu; Mondal, Animesh; Ghosh, Prasanta; Rudra, Sonali; Mukhopadhyay, Chhanda Abstract : A new series of highly-functionalized spiro compounds of pyrrole were synthesized by a one pot, step-economic condensation of isatin, arylamine and β-keto...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t Volume : 81, Issue : 9, Pages : 1956-1961 DOI : 10.1021/acs.jnatprod.8b00036 Author : Ghate, Nikhil B.; Chaudhuri, Dipankar; Panja, Sourav; Singh, Sudhir S.; Gupta, Gajendra; Lee, Chang Yeon; Mandal, Nripendranath Abstract : The search for new plant-based anti-inflammatory drugs continues in order to overcome the detrimental side effects of conventional anti-inflammatory...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t Volume : 7, Issue : 1, Pages : 1-17 DOI : 10.1038/s41598-017-14776-0 Author : Yasmin, Sabina; Capone, Fabio; Laghezza, Antonio; Piaz, Fabrizio Dal; Loiodice, Fulvio; Vijayan, Viswanathan; Devadasan, Velmurugan; Mondal, Susanta K.; Atli, Ozlem; Baysal, Merve; Pattnaik, Ashok K.; Jayaprakash, Venkatesan; Lavecchia, Antonio Abstract : Peroxisome proliferator-activated receptor γ has received significant...

Published in: Journal, Article, Volume : 21, Issue : 3, Pages : 200-208 DOI : 10.1177/1087054713494004 Author : Das Bhowmik, Aneek; Sarkar, Kanyakumarika; Ghosh, Paramita; Das, Manali; Bhaduri, Nipa; Sarkar, Keka; Ray, Anirban; Sinha, Swagata; Mukhopadhyay, Kanchan Abstract : OBJECTIVE: ADHD is frequently detected in boys though there is no established cause. One possibility is that genes predisposing to ADHD...

Published in: Journal, Volume : 57, Issue : 29, Pages : 3140-3145 DOI : 10.1016/j.tetlet.2016.06.019 Author : Pai, Gita; Chattopadhyay, Asoke P. Abstract : Cu nanoparticles promoted N-arylation of NH-heterocycles, e.g., I with aryl halides ArX [Ar = 4-H3CC6H4, 2,4-(Cl)2C6H3, 4-O2NC6H4, etc.; X = Cl, I] is an effective and inexpensive method. In this synthetic protocol, good to excellent...

Published in: Journal, Volume : 13, Issue : 2, Pages : 127-134 DOI : 10.2174/1570178613666151124200300 Author : Joardar, Soumen; Chakravorty, Santanu; Das, Sakti P. Abstract : Simple, convenient, one step protocol for the synthesis of isobenzofuran-1(3H)-ones (phthalides) from phthalate esters in moderate to good yields were developed. Short and effective route to prepare two bioactive butyrolactones, viz., maculalactone A...

Published in: Journal, Article, Volume : 59, Issue : 3, Pages : 1116-1139 DOI : 10.1021/acs.jmedchem.5b01704 Author : Igawa, Hideyuki; Takahashi, Masashi; Kakegawa, Keiko; Kina, Asato; Ikoma, Minoru; Aida, Jumpei; Yasuma, Tsuneo; Kawata, Yayoi; Ashina, Shuntaro; Yamamoto, Syunsuke; Kundu, Mrinalkanti; Khamrai, Uttam; Hirabayashi, Hideki; Nakayama, Masaharu; Nagisa, Yasutaka; Kasai, Shizuo; Maekawa, Tsuyoshi Abstract : Aiming to discover melanin-concentrating hormone...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t Volume : 349, Issue : 1, Pages : 9-19 DOI : 10.1002/ardp.201500317 Author : Badavath, Vishnu N.; Baysal, Ipek; Ucar, Guelberk; Mondal, Susanta K.; Sinha, Barij N.; Jayaprakash, Venkatesan Abstract : Ferulic acid has structural similarity with curcumin which is being reported for its monoamine oxidase (MAO) inhibitory activity. Based on this...

Published in: Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Volume : 354, Issue : 3, Pages : 261-268 DOI : 10.1124/jpet.115.224519 Author : BLi, Mei-Hong; Swenson, Rolf; Harel, Miriam; Jana, Sampa; Stolarzewicz, Erik; Hla, Timothy; Shapiro, Linda H.; Ferrer, Fernando Abstract : The bioactive lipid sphingosine-1-phosphate (S1P) and its receptors (S1P1-5) play critical roles in many pathol....

Published in: Journal, Article, Volume : 11, Issue : 42, Pages : 269-276 DOI : 10.4103/0973-1296.153078 Author : Chaudhuri, Dipankar; Ghate, Nikhil Baban; Singh, Sudhir Shankar; Mandal, Nripendranath Abstract : Background:Spondias pinnata has been reported for its efficient anticancer effects, but the studies were mostly focused on its extract Objective: Since its bioactive compounds are largely unknown, this study was...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 120, Issue : 4, Pages : 941-949 DOI : 10.1213/ANE.0000000000000629 Author : Banerjee, Manish; Baranwal, Atul; Saha, Soumya; Saha, Ashis; Priestley, Tony Abstract : Background: Currently approved local anesthetic drugs provide relatively brief local anesthesia that is appropriate and even desirable in some settings, but an extended duration of action...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 67, Issue : 7, Pages : 951-962 DOI : 10.1111/jphp.12397 Author : Sarkar, Ratul; Mondal, Chaitali; Bera, Rammohan; Chakraborty, Sumon; Barik, Rajib; Roy, Paramita; Kumar, Alekh; Yadav, Kirendra K.; Choudhury, Jayanta; Chaudhary, Sushil K.; Samanta, Samir K.; Karmakar, Sanmoy; Das, Satadal; Mukherjee, Pulok K.; Mukherjee, Joydeep; Sen, Tuhinadri Abstract...

Published in: Journal, Volume : 26, Issue : 3, Pages : 359-362 DOI : 10.1055/s-0034-1379427 Author : Joardar, Soumen; Chakravorty, Santanu; Das, Saktipada Abstract : Tricyclic sultams were synthesized through sulfonation and a palladium-mediated Sonogashira cross-coupling followed by a reductive Heck cyclization. The procedure is straightforward and was carried out under ligand-free conditions.

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 13, Issue : 11, Pages : 3211-3219 DOI : 10.1039/c4ob02475c Author : Malhotra, Rajesh; Dey, Tushar K.; Basu, Sourav; Hajra, Saumen Abstract : A two step protocol is developed for the efficient synthesis of enantiopure N-Boc-dihydrobenzo[b]-1,4-oxazine-3-carboxylic acids from serine derived cyclic sulfamidate via intramol. arylamination. The RuPhos Palladacycle along with...

Published in: Journal, Volume : 46, Issue : 22, Pages : 3121-3132 DOI : 10.1055/s-0034-1378454 Author : Joardar, Soumen; Bhattacharyya, Anjan; Das, Saktipada Abstract : A new and efficient palladium on carbon catalyzed one-pot intramol. nitro reduction/cyclization reaction has been developed for the preparation of a series of substituted benzimidazoles, including some novel ring-fused [1,2-a]-tricyclic, [1,2-a]-tetracyclic, and chiral benzimidazoles. The...

Published in: Journal, Volume : 4, Issue : 89, Pages : 48344-48347 DOI : 10.1039/c4ra06617k Author : Malhotra, Rajesh; Ghosh, Amit; Dutta, Swarup; Dey, Tushar K.; Basu, Sourav; Hajra, Saumen Abstract : Asym. synthesis of O-Me doxanthrine is accomplished with high diastereo- and enantioselectivity from β-aryloxyamino acid derived from D-serine.

Published in: Journal, Volume : 196, Pages : 345-351 DOI : 10.1016/j.snb.2014.02.031 Author : Diwan, Uzra; Kumar, Ajit; Kumar, Virendra; Upadhyay, K. K.; Roychowdhury, P. K. Abstract : A fluorescein-sugar conjugated chromo-fluorogenic turn ‘on’ probe (FG) has been synthesized for detection of Cu2+. The FG comprises of fluorescein as an efficient fluorophore and a sugar moiety, viz., galactose...

Published in: Journal, Article, Volume : 24, Issue : 3, Pages : 949-953 DOI : 10.1016/j.bmcl.2013.12.063 Author : Gillespie, Paul; Goodnow, Robert A.; Saha, Goutam; Bose, Gopal; Moulik, Kakali; Zwingelstein, Catherine; Myers, Michael; Conde-Knape, Karin; Pietranico-Cole, Sherrie; So, Sung-Sau Abstract : We designed and synthesized a novel series of phenylamino- and phenoxy-substituted pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. SAR studies indicated...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 460, Issue : 1-2, Pages : 949-953 DOI : 10.1016/j.ijpharm.2013.10.055 Author : Choudhury, Hira; Gorain, Bapi; Karmakar, Sanmoy; Biswas, Easha; Dey, Goutam; Barik, Rajib; Mandal, Mahitosh; Pal, Tapan Kumar Abstract : Paclitaxel, a potential anticancer agent against solid tumors has been restricted from its oral use due to poor water...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 82, Issue : 1, Pages : 312-318 DOI : 10.1016/j.talanta.2010.04.041 Author : Upadhyay, K. K.; Mishra, Rakesh K.; Kumar, Virendra; Chowdhury, P. K. Roy Abstract : A new coumarin based hydrazone (receptor 1) synthesized by modifying one of our earlier reported receptor detected fluoride ion selectively through naked eye in...

Published in: Journal, Article, Research Support, Non-U.S. Gov’t, Volume : 13, Issue : 11, Pages : 3211-3219 DOI : 10.1039/c4ob02475c Author : Malhotra, Rajesh; Dey, Tushar K.; Basu, Sourav; Hajra, Saumen Abstract : A two step protocol is developed for the efficient synthesis of enantiopure N-Boc-dihydrobenzo[b]-1,4-oxazine-3-carboxylic acids from serine derived cyclic sulfamidate via intramol. arylamination. The RuPhos Palladacycle along with...

Published in: Journal, Volume : 26, Issue : 3, Pages : 359-362 DOI : 10.1055/s-0034-1379427 Author : Joardar, Soumen; Chakravorty, Santanu; Das, Saktipada Abstract : Tricyclic sultams were synthesized through sulfonation and a palladium-mediated Sonogashira cross-coupling followed by a reductive Heck cyclization. The procedure is straightforward and was carried out under ligand-free conditions.

Published in: Journal, Volume : 46, Issue : 22, Pages : 3121-3132 DOI : 10.1055/s-0034-1378454 Author : Joardar, Soumen; Bhattacharyya, Anjan; Das, Saktipada Abstract : A new and efficient palladium on carbon catalyzed one-pot intramol. nitro reduction/cyclization reaction has been developed for the preparation of a series of substituted benzimidazoles, including some novel ring-fused [1,2-a]-tricyclic, [1,2-a]-tetracyclic, and chiral benzimidazoles. The...

Published in: Journal, Volume : 4, Issue : 89, Pages : 48344-48347 DOI : 10.1039/c4ra06617k Author : Malhotra, Rajesh; Ghosh, Amit; Dutta, Swarup; Dey, Tushar K.; Basu, Sourav; Hajra, Saumen Abstract : Asym. synthesis of O-Me doxanthrine is accomplished with high diastereo- and enantioselectivity from β-aryloxyamino acid derived from D-serine.

Published in: Journal, Volume : 196, Pages : 345-351 DOI : 10.1016/j.snb.2014.02.031 Author : Diwan, Uzra; Kumar, Ajit; Kumar, Virendra; Upadhyay, K. K.; Roychowdhury, P. K. Abstract : A fluorescein-sugar conjugated chromo-fluorogenic turn ‘on’ probe (FG) has been synthesized for detection of Cu2+. The FG comprises of fluorescein as an efficient fluorophore and a sugar moiety, viz., galactose...

Published in: Journal, Article, Volume : 24, Issue : 3, Pages : 949-953 DOI : 10.1016/j.bmcl.2013.12.063 Author : Gillespie, Paul; Goodnow, Robert A.; Saha, Goutam; Bose, Gopal; Moulik, Kakali; Zwingelstein, Catherine; Myers, Michael; Conde-Knape, Karin; Pietranico-Cole, Sherrie; So, Sung-Sau Abstract : We designed and synthesized a novel series of phenylamino- and phenoxy-substituted pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. SAR studies indicated...

Published in: Journal, Volume : 69, Issue : 43, Pages : 8994-9000 DOI : 10.1016/j.tet.2013.08.042 Author : Malhotra, Rajesh; Chakrabarti, Sagar; Dey, Tushar K.; Dutta, Swarup; Alapati, Krishna Babu; Dutta, Shantanu; Roy, Subho; Basu, Sourav; Hajra, Saumen Abstract : Protection group of amino- and tethered o-arene functionality of 1,4-aryl-2-amino-1-butanol derived from l-serine dictates the cyclization mode under acidic conditions leading...

Published in: Journal, Article, Volume : 42, Pages : 92-103 DOI : 10.1016/j.jmgm.2013.02.011 Author : Basu, Sohini; Sen, Srikanta Abstract : Designing proteins with enhanced thermostability has been a major interest of protein engineering because of its potential industrial applications. Here, we have presented a computational method for designing dimeric thermostable protein based on rational mutations on a...

Published in: Journal, Volume : 1035, Pages : 174-182 DOI : 10.1016/j.molstruc.2012.09.017 Author : Kumar, Ajit; Kumar, Virendra; Neeraj; Upadhyay, K. K.; Roychowdhury, P. K. Abstract : Three simple Schiff base receptors I-III containing pyrene skeletons were designed and synthesized. The intramol. hydrogen bonding between aldimine N-atom and phenolic OH of these Schiff bases play a crucial role...

Published in: Journal, Volume : 24, Issue : 5-6, Pages : 278-284 DOI : 10.1016/j.tetasy.2013.02.003 Author : Malhotra, Rajesh; Chakrabarti, Sagar; Ghosh, Amit; Ghosh, Rajib; Dey, Tushar K.; Dutta, Swarup; Dutta, Shantanu; Roy, Subho; Basu, Sourav; Hajra, Saumen Abstract : A divergent and scalable asym. synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo-...

Published in: Journal, Article, Volume : 53, Issue : 2, Pages : 423-434 DOI : 10.1021/ci300474h Author : Basu, Sohini; Sen, Srikanta Abstract : Structure and dynamics both are known to be important for the activity of a protein. A fundamental question is whether a thermophilic protein and its mesophilic homolog exhibit similar dynamics at their resp. optimal growth temperatures...

Published in: Journal, Volume : 2013, Issue : 4, Pages : 772-780 DOI : 10.1002/ejoc.201201288 Author : Malhotra, Rajesh; Ghosh, Rajib; Dey, Tushar K.; Chakrabarti, Sagar; Ghosh, Amit; Dutta, Swarup; Asijaa, Sonika; Roy, Subho; Dutta, Shantanu; Basu, Sourav; Hajra, Saumen Abstract : A catalyst-free conjugate addition of indoles and pyrroles to 1,2-dihydro-3-nitronaphthalenes in water has been developed. A variety...

Published in: Journal, Volume : 1027, Pages : 167-174 DOI : 10.1016/j.molstruc.2012.06.020 Author : Mishra, Rakesh K.; Kumar, Virendra; Diwan, Uzra; Upadhyay, K. K.; Roy Chowdhury, P. K. Abstract : The stepwise substitution of appropriate groups over the 3-[(2,4-dinitro-phenyl)-hydrazono]-butyric acid Et ester (R3) lead receptor R1 which showed selectivity towards fluoride in DMSO. The UV-vis and 1H NMR...

Published in: Journal, Volume : 354, Issue : 13, Pages : 2433-2437, S2433/1-S2433/39 DOI : 10.1002/adsc.201200241 Author : Hajra, Saumen; Ghosh, Rajib; Chakrabarti, Sagar; Ghosh, Amit; Dutta, Swarup; Dey, Tushar K.; Malhotra, Rajesh; Asijaa, Sonika; Roy, Subho; Dutta, Shantanu; Basu, Sourav Abstract : A highly enantioselective (up to 91% ee) rhodium-catalyzed asym. addition of arylboronic acids has been achieved leading...

Published in: Journal, Volume : 52, Issue : 39, Pages : 5098-5103 DOI : 10.1016/j.tetlet.2011.07.110 Author : Ghosh, Kumaresh; Kar, Debasis; Chowdhury, Purnendu Roy Abstract : Pyrene appended benzimidazolium-based simple cleft (I) has been synthesized. The open cleft of I distinguishes H2PO4- and F- selectively by showing binding induced different emission characteristics in CH3CN. The chemosensor I also functions in...

Published in: Journal, Volume : 22, Issue : 14-15, Pages : 1522-1529 DOI : 10.1016/j.tetasy.2011.08.014 Author : Malhotra, Rajesh; Ghosh, Amit; Ghosh, Rajib; Chakrabarti, Sagar; Dutta, Swarup; Dey, Tushar K.; Roy, Subho; Basu, Sourav; Hajra, Saumen Abstract : A scalable asym. synthesis of trans-2-amino-6,7-dimethoxy-1-phenyltetralin and its N-nosyl derivative have been achieved from Garner aldehyde derived from easily available D-serine...

Published in: Journal, Article, Volume : 46, Issue : 2, Pages : 618-630 DOI : 10.1016/j.ejmech.2010.11.042 Author : Sinha, Nandita; Sen, Srikanta Abstract : A QSAR based predictive model of hERG activity in terms of global descriptors’ has been developed and evaluated. The QSAR was developed by training 77 compounds covering a wide range of activities and was validated...

Published in: Journal, Article, Volume : 20, Issue : 24, Pages : 7414-7420 DOI : 10.1016/j.bmcl.2010.10.030 Author : McGuinness, Brian F.; Ho, Koc-Kan; Stauffer, Tara M.; Rokosz, Laura L.; Mannava, Neelima; Kultgen, Steven G.; Saionz, Kurt; Klon, Anthony; Chen, Weiqing; Desai, Hema; Rogers, W. Lynn; Webb, Maria; Yin, Juxing; Jiang, Yan; Li, Tailong; Yan, Hao; Jing, Konghua; Zhang, Shengting;...

Published in: Journal, Article, Volume : 49, Issue : 7, Pages : 1741-1750 DOI : 10.1021/ci900183m Author : Basu, Sohini; Sen, Srikanta Abstract : In spite of considerable improvement of our understanding of factors responsible for protein thermostability, rational designing of thermostable variants of mesophilic proteins is not yet fully established. The present paper describes an effective computational strategy that...

Published in: Journal, Article, Volume : 22, Issue : 18, Pages : 1657-1659 DOI : 10.1080/14786410701876635 Author : Pandey, M. B.; Singh, A. K.; Singh, U.; Singh, S.; Pandey, V. B. Abstract : A new chalcone glycoside, chalcone-2′,4-dihydroxy-4′-O-β-D-glucoside was isolated from Rhamnus nipalensis together with sitosterol, lupeol, di-O-methyldaidzein, kaempferol-4′-methylether, quercetin, physcion, sitosterol glucoside, emodin and their structures established by spectroscopic...

Published in: Journal, Volume : 45, Issue : 3, Pages : 741-744 DOI : 10.1002/jhet.5570450317 Author : Roychowdhuary, P. K.; Upadhay, K. K.; Mishra, Rakesh K.; Kumar, Ajit; Mehrotra, Sangeeta; Srivastava, Sugandh; Upadhyay, Shalini Abstract : A series of 4-thiazolidinones having triazinethione moieties have been synthesized by the systematic chem. modification of S-benzylmercapto-1-aryl-4-(4-methoxyphenyl)-1,6-dihydro-1,3,5-triazine-6-thione.

Published in: Journal, Article, Volume : 22, Issue : 3, Pages : 219-221 DOI : 10.1080/14786410601133483 Author : Pandey, Manoj Bhushan; Singh, Ashok Kumar; Singh, Virendra Pratap; Pandey, Vidya Bhushan Abstract : A new cyclopeptide alkaloid, sativanine-M, together with known alkaloid nummularine-P were isolated from the stem bark of Zizyphus sativa and identified by spectral anal.

Published in: Journal, Article, Volume : 25, Issue : 1, Pages : 158-168 DOI : 10.1016/j.jmgm.2005.11.004 Author : Roy, Sujata; Sen, Srikanta Abstract : We have demonstrated that the methods of mol. modeling and mol. dynamics simulation might be used to assess whether a specific mutation in the DNA would destabilize a known DNA-protein complex. The approach is based on...

Published in: Journal, Article, Volume : 16, Issue : 16, Pages : 4252-4256 DOI : 10.1016/j.bmcl.2006.05.074 Author : Amarasinghe, Kande K. D.; Evidokimov, Artem G.; Xu, Kevin; Clark, Cynthia M.; Maier, Matthew B.; Srivastava, Anil; Colson, Anny-Odile; Gerwe, Gina S.; Stake, George E.; Howard, Brian W.; Pokross, Matthew E.; Gray, Jeffrey L.; Peters, Kevin G. Abstract : The sulfamic acid...

Published in: Journal, Article, Volume : 46, Issue : 3, Pages : 1394-1401 DOI : 10.1021/ci050459i Author : Biswas, Dhrubajyoti; Roy, Sujata; Sen, Srikanta Abstract : A knowledge-based simple score has been developed for indexing the oral druglikeness of compounds based on the concept that oral druglikeness should be independent of the drug targets and, thus, are closely related...

Published in: Journal, Volume : 47, Issue : 22, Pages : 3629-3631 DOI : 10.1016/j.tetlet.2006.03.155 Author : Amarasinghe, Kande K. D.; Maier, Matthew B.; Srivastava, Anil; Gray, Jeffrey L. Abstract : A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acid esters and amidoximes in the presence of potassium carbonate was employed to synthesize a variety of...

Published in: Journal, Comparative Study, Article, Volume :22, Issue : 6, Pages : 707-718 DOI : 10.1080/07391102.2005.10507037 Author : Roy, Sujata; Sen, Srikanta Abstract : The 3D structure of neither Hoxc8 nor Hoxc8-DNA complex is known. The repressor protein Hoxc8 binds to the TAAT stretch of the promoter of the osteopontin gene and modulates its expression. Over expression...

Published in: Journal, General Review, Article, Review Volume :4, Issue : 6, Pages : 711-722 DOI : 10.2174/1566524043360302 Author : Chowdhury, Arnab Roy; Majumder, Hemanta K. Abstract : A review. Current biomedical research has its focus on the search for newer intervention strategies to control public health impact of parasitic diseases. The dramatic advances of mol. and cellular biol....

Published in: Journal, Volume :41, Issue : 1, Pages : 51-55 DOI : 10.1002/jhet.5570410108 Author : Bhaumik, Kankan; Akamanchi, K. G. Abstract : 2,4-Dinitroimidazole (I), an important starting material for nitroimidazooxazole and nitroimidazooxazine types of antitubercular agents was synthesized by rearrangement of 1,4-dinitroimidazole under microwave irradiation Various new nitroimidazooxazoles analogs were prepared from I and were tested preliminarily against...

Published in: Journal, Volume : 45, Issue : 6, Pages : 1275-1277 DOI : 10.1016/j.tetlet.2003.11.135 Author : Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Janusz, John J.; Ridgeway, James M.; Seibel, William L. Abstract : The solid-phase synthesis of a series of imidazo[1,2-b]pyrazol-2-ones, an interesting 5,5-fused ring system, based on diverse set of hydrazine acids and...

Published in: Journal, Volume :44, Issue : 49, Pages : 8861-8863 DOI : 10.1016/j.tetlet.2003.09.178 Author : Naskar, Dinabandhu; Roy, Amrita; Seibel, William L. Abstract : 1,3,5-Tri-Oxygenated benzenes can serve as substrates for the Petasis boronic acid reaction, providing a practical synthetic route for the two C-C bond formation of α-(1,3,5-tri-oxygenated phenyl)carboxylic acids. The scope and limitations of this method...

Published in: Journal, Volume :44, Issue : 49, Pages : 8865-8868 DOI : 10.1016/j.tetlet.2003.09.179 Author : Naskar, Dinabandhu; Roy, Amrita; Seibel, William L.; Portlock, David E. Abstract : An efficient synthesis of N-hydroxy or alkoxy-α-aminocarboxylic acids and N-(tert-Bu sulfinyl)-α-amino carboxylic acids was developed from N,O-alkyl or hydroxylamines and tert-Bu sulfinamide utilizing a Petasis boronic acid-Mannich reaction. The scope and...

Published in: Journal, Volume :44, Issue : 33, Pages : 6297-6300 DOI : 10.1016/s0040-4039(03)01524-7 Author : Naskar, Dinabandhu; Roy, Amrita; Seibel, William L.; West, Laura; Portlock, David E. Abstract : The synthetic utility of a tandem Petasis-Ugi multi-component condensation and 1,3-diisopropylcarbodiimide condensation reactions have been employed to efficiently prepare two to four-dimensional libraries of aza-β-lactams.

Published in: Journal, Volume : 44, Issue : 28, Pages : 5365-5368 DOI : 10.1016/s0040-4039(03)01180-8 Author : Portlock, David E.; Naskar, Dinabandhu; West, Laura; Seibel, William L.; Gu, Titan; Krauss, Howard J.; Peng, X. Sean; Dybas, Paul M.; Soyke, Edward G.; Ashton, Stephen B.; Burton, Jonathan Abstract : The synthesis of Δ3,10-isoquinine (5Z,5E) and Δ3,10-isoquinidine (6Z,6E) was achieved in one-step..

Published in: Journal, Volume : 44, Issue : 27, Pages : 5121-5124 DOI : 10.1016/s0040-4039(03)01119-5 Author : Portlock, David E.; Naskar, Dinabandhu; West, Laura; Ostaszewski, Ryszard; Chen, Jack J. Abstract : Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis-Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is...

Published in: Journal, Volume : 44, Issue : 3, Pages : 603-605 DOI : 10.1016/s0040-4039(02)02619-9 Author : Portlock, David E.; Ostaszewski, Ryszard; Naskar, Dinabandhu; West, Laura Abstract : Amino acids with three points of diversity generated from the Petasis boronic acid-Mannich reaction can be used as one of the four components of the Ugi condensation to prepare six...

Published in: Journal, Volume : 44, Issue : 14, Pages : 3009-3011 DOI : 10.1016/s0040-4039(03)00398-8 Author : Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Seibel, William L. Abstract : A simple procedure for the synthesis and further functionalization of 4,5-diaminopyrazoles using mild conditions is reported herein. The desired products were obtained in good yield, and the...

Published in: Journal, Volume : 44, Issue : 10, Pages : 2153-2155 DOI : 10.1016/s0040-4039(03)00180-1 Author : Blass, Benjamin E.; Coburn, Keith R.; Faulkner, Amy L.; Seibel, William L.; Srivastava, Anil Abstract : Functionalized 1,2,3-triazoles were prepared in a one-pot, two-step synthesis from alkyl halides and alkynes using a polymer supported azide. Two different base resins were examined The chem....

Published in: Journal, Volume : 43, Issue : 45, Pages : 8165-8167 DOI : 10.1016/s0040-4039(02)01956-1 Author : Blass, Benjamin E.; Coburn, Keith R.; Faulkner, Amy L.; Liu, Song; Ogden, Adam; Portlock, David E.; Srivastava, Anil Abstract : The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate...

Published in: Journal, Volume : 43, Issue : 38, Pages : 6845-6847 DOI : 10.1016/s0040-4039(02)01511-3 Author : Portlock, David E.; Naskar, Dinabandhu; West, Laura; Li, Min Abstract : R1CONHNHR2 [R1 = OCMe3, OCH2Ph, NH2; R2 = cyclohexylmethyl, Me2CHCH2, MeO2CCH2, PhCH2, Ph, 4-MeC6H4, 4-O2NC6H4,2-pyridyl, H, EtO2CCH2] can serve as amine substrates for...

Published in: Journal, Volume : 45, Issue : 3, Pages : 619-621 DOI : 10.1016/j.tetlet.2003.10.177 Author : Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Janusz, John J.; Ridgeway, James M.; Seibel, William L. Abstract : The solution phase synthesis of a series of imidazo[1,2-b]pyrazol-2-ones, e.g., I, a fused 5,5-ring system, is described. The heterocyclization of α-hydrazino...