Published In: Tetrahedron Letters (2026)
DOI: 10.1016/j.tetlet.2026.156228
Authors
An efficient and stereospecific protocol was developed for the rapid synthesis of dendrodolide I from (R)-glycidol, (S)-homoglycidol, and (R)-but-3-yn-2-ol as readily available chiral synthons. This was achieved by utilizing regioselective ring opening of epoxides, Steglich esterification, and ring-closing metathesis (RCM) as key steps. Moreover, dendrodolide J can also be achieved utilizing the same protocol, altering one chiral synthon, i.e., (R)-glycidol with (S)-glycidol.
