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One-pot synthesis of 1,2,4-oxadiazoles from carboxylic acid esters and amidoximes using potassium carbonate

Published in: Journal, Volume : 47, Issue : 22, Pages : 3629-3631

DOI : 10.1016/j.tetlet.2006.03.155

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A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acid esters and amidoximes in the presence of potassium carbonate was employed to synthesize a variety of mono-, bis- and tris-oxadiazoles in moderate to excellent yields.

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