Published in: Journal, Volume : 22, Issue : 14-15, Pages : 1522-1529
Authors
A scalable asym. synthesis of trans-2-amino-6,7-dimethoxy-1-phenyltetralin and its N-nosyl derivative have been achieved from Garner aldehyde derived from easily available D-serine using a stereoselective PhMgBr addition, Wittig reaction and TFA-mediated Friedel-Crafts cyclization as the key steps. The synthesis of dihydrexidine is accomplished from the N-nosyl-2-amino-1-phenyltetralin.