Published In: Synthetic Communications (2026)
DOI: 10.1080/00397911.2026.2706131
Authors
An efficient stereospecific protocol for the formal synthesis of benzannulated macrolactone 11-β-methoxycurvularin was established. The key transformations include the regioselective epoxide opening and Steglich esterification for the formation of the polyketide chain and intramolecular Friedel-Crafts acylation for macrocyclization, providing an efficient route toward the synthesis of related biologically active natural products.
