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2,4-Dinitroimidazole: Microwave assisted synthesis and use in synthesis of 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole analogues with antimycobacterial activity

Published in: Journal, Volume :41, Issue : 1, Pages : 51-55

DOI : 10.1002/jhet.5570410108

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2,4-Dinitroimidazole (I), an important starting material for nitroimidazooxazole and nitroimidazooxazine types of antitubercular agents was synthesized by rearrangement of 1,4-dinitroimidazole under microwave irradiation Various new nitroimidazooxazoles analogs were prepared from I and were tested preliminarily against Mycobacterium tuberculosis, H37Rv strain. Some were found to be active.

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