At TCG Lifesciences (TCGLS), we offer deep expertise in the synthesis of structurally complex natural products and their analogues, supporting discovery programs that demand advanced synthetic problem-solving, stereochemical precision, and innovative route design.
Our scientists with strong academic and industry experience in natural product synthesis achieved efficient and scalable synthetic solutions towards preclinical research on cardiovascular, anti-inflammatory, anti-cancer and a few other therapeutic areas.
We have successfully demonstrated our capabilities in the multi-step total synthesis of diverse natural product classes spanning polyketides, lignans, alkaloids, macrocycles, and highly functionalized bioactive scaffolds across different collaborations.
Our Core Capabilities
Our synthetic chemistry expertise encompasses the design and execution of complex natural product syntheses across multiple structural classes, including:
Prostacyclin-like molecular frameworks associated with cardiovascular and anti-inflammatory therapeutic research
Polyketide natural products, including Spiculoic acid derivatives and Epothilones, widely explored for anticancer and cytotoxic activities
Polyisoprenylated phloroglucinol natural products investigated for antimicrobial, anticancer, and neuroprotective properties
Function-oriented synthesis of Peloruside A analogues relevant to microtubule stabilization and oncology research
Necine base alkaloids including (+/–)-Macronecine and (+/–)-Supinidine, important intermediates in alkaloid and medicinal chemistry programs
Aryl tetralin lignans such as (-)-Podophyllotoxin and (-)-Picropodophyllin, recognized for their significance in anticancer drug discovery
Furofuran lignans including (+)-Sesamin and (+)-Aschantin, studied for antioxidant and bioactive properties
Dibenzylbutyrolactone lignans such as (-)-Parabenzlactone and (-)-Yatein, explored for diverse biological activities including anticancer potential
Complex anticancer molecules such as Eribulin, involving advanced synthetic strategies for highly functionalized molecular architectures
These programs demonstrate the group’s expertise in multistep synthesis, stereochemical control, and the synthesis of structurally intricate natural product architectures.