Macrocyclic compounds are increasingly recognized as powerful scaffolds in drug discovery due to their structural complexity, conformational rigidity, and ability to engage challenging biological targets.
At TCGLS, we possess deep expertise in the design and synthesis of macrocyclic compounds, supported by a comprehensive toolbox of cyclization methodologies.
Our Core Capabilities
Our capabilities encompass a wide range of advanced strategies, including:
Ring-Closing Metathesis (RCM)
Lactam Cyclization
Mitsunobu Cyclization
Disulfide Bond Formation
Click Chemistry
Sulfonamide Formation
Substitution-Based Cyclization
Reductive Amination
Metal Catalyzed C-C / C-N Bond Formation
Several Other Approaches
Leveraging strong methodological expertise, TCGLS constructs diverse scaffolds—from ethers, sulfonamides, lactones, and lactams to complex bicyclic and tricyclic architectures—aligned with modern drug discovery needs. Combining synthetic versatility, operational efficiency, and scalable processes, we have delivered macrocyclic compounds from early discovery through multi-step synthesis to gram scale, supporting complex macrocyclic programs across drug discovery and development.