Lipid Chemistry

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Following the approval of Onpattro in 2018 and the global deployment of COVID-19 mRNA vaccines in 2020, lipid nanoparticles (LNPs) have emerged as key carriers for drug delivery, genome editing, and biologics. At TCG Lifesciences (TCGLS), with around 10 years of lipid chemistry experience, we have the following capabilities and service offerings.

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Our Core Capabilities

TCGLS supports synthesis of diverse lipid classes including:

  • Ionizable lipids
  • PEGylated lipids
  • Helper lipids (phospholipids and sterol lipids such as Cholesterol)
  • Other functional lipids

  • Custom Lipid Synthesis
    • Delivery in FTE or FFS models
    • R&D to multi-kilogram scale-up synthesis, supporting GMP and GLP standards for quality and reliability
    • Capability for long-chain and branched lipid synthesis
  • Advanced Purification Infrastructure
    • Prep-HPLC, SFC, CAD/ELSD-based flash chromatography, diafiltration
    • Mass-triggered auto-purification using 3100 SQD/SQD2 systems
  • Comprehensive Analytical Characterization
    • UPLC-LC-MS (ELSD), GPC, HPLC with VWD, CAD, DAD
    • ¹H-NMR, ¹³C-NMR, ³¹P-NMR, Q-NMR, ESI-MS, and LCMS
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