TCGLS offers extensive expertise in library synthesis and custom synthesis services, supporting pharmaceutical, biotechnology, agrochemical, animal health, and allied industries in accelerating discovery programs through the rapid generation of high-quality compound libraries. With around 20 years of experience in parallel synthesis, we have successfully delivered focused, diverse, and tailor-made libraries for hit identification and lead optimization.
Leveraging advanced synthesis platforms, parallel medicinal chemistry approaches, and strong expertise in heterocyclic, multistep, and transition metal-mediated chemistries, TCGLS enables efficient exploration of chemical space with speed and precision. Our capabilities include target-focused libraries, PROTAC libraries, scaffold modifications, and custom compound synthesis, supported by robust analytical, purification, and compound management infrastructure for high-throughput delivery of high-quality compounds.
Key Features of Our Library Synthesis Services
Extensive in-house monomer inventory (>25,000 building blocks) enabling rapid project initiation and broad chemical space exploration
Highly experienced parallel synthesis team (65+ scientists) supported by dedicated analytical, purification, and compound management groups
Proven expertise in executing focused, target-based, and high-diversity libraries across hit generation, hit follow-up, and lead optimization programs
Advanced synthesis infrastructure including parallel reactors, microwave platforms, carousel systems, orbital/environmental shakers, and high-throughput workstations
Flexible delivery formats including assay-ready DMSO plates under controlled conditions or powder in vials based on client requirements
Reward–penalty execution model supporting timeline accountability and efficient project management
Rapid purification and solvent removal enabled through automated mass-directed purification systems and high-throughput evaporation platforms
Our Core Capabilities & Infrastructure
Why Partner with TCGLS for Library Synthesis?
Dedicated team of experienced parallel synthesis scientists supported by advanced analytical and compound management infrastructure
Proven capability in delivering focused, target-based, and large-scale screening libraries with high success rates and rapid turnaround
Advanced high-throughput synthesis, purification, and compound processing platforms enabling accelerated project execution
Strong expertise in complex medicinal chemistry transformations, scaffold diversification, and PROTAC library synthesis
Flexible and scalable workflows adaptable to different library sizes, chemistries, and project timelines
Robust analytical and purification capabilities ensuring high-quality compound delivery with consistent purity standards
Extensive monomer inventory (>25,000) enabling faster project initiation and broad chemical space coverage
Integrated project execution model with strong communication, validation-driven development, and reliable on-time delivery
TCGLS delivers high-quality, scalable, and scientifically robust library synthesis solutions that accelerate medicinal chemistry and drug discovery programs from hit identification through lead optimization.
to explore how TCGLS can support your library synthesis needs.